| Feature | Description |
|---|---|
| Active Ingredient | Sildenafil Citrate |
| Dosage Form | Tablet |
| Common Dosages | 50 mg, 100 mg |
| Onset of Action | 30 to 60 minutes |
| Duration | 4 to 6 hours |
| Link | Learn More |
Chemical Structure of Sildenafil Citrate
The compound Sildenafil Citrate, the active ingredient in Caverta, belongs to the class of phosphodiesterase type 5 inhibitors. Its molecular formula is C22H30N6O4S. This compound contains complex rings and functional groups essential for its pharmacological activity. Its structural features facilitate the selective inhibition of phosphodiesterase, thereby enhancing blood flow in specific areas.
This selectivity is crucial for treating erectile dysfunction by modulating cyclic guanosine monophosphate levels in the vascular tissue. Understanding the nuances of its chemical architecture helps in the synthesis of analogs for improved efficacy. Chemical characteristics, such as its crystalline nature, ensure stability and shelf-life. The balance of hydrophobic and hydrophilic interactions influences its bioavailability.
Dosage Information for Caverta
Caverta tablets are available primarily in 50 mg and 100 mg strengths. The recommended initial dose for most patients is 50 mg, taken approximately one hour before anticipated sexual activity. Depending on efficacy and tolerability, the dose can be adjusted to 100 mg or decreased to 25 mg. The frequency of administration should not exceed one dose per day.
Food intake can influence absorption. A high-fat meal may delay the onset of action, thus affecting the therapeutic window. Patients are advised to adhere to prescribed dosages, as variations can lead to suboptimal outcomes or heightened side effects. Physicians might tailor doses based on individual health status and concomitant medications.
Warning & Precautions for Caverta Use
Caution is paramount when administering Caverta. It is contraindicated in patients using nitrates due to severe hypotension risk. It is crucial to assess cardiovascular health before prescribing, as sexual activity presents a cardiac risk. Patients with anatomical penile deformation or predisposition to priapism require special attention.
Side effects include headache, flushing, and dyspepsia. Patients should cease use if they experience sudden vision loss or hearing changes. Monitoring for interactions with other medications, especially those metabolized by CYP3A4, is vital. Alcohol can potentiate side effects, thus moderation is recommended.
Caverta Interactions to Consider
Interaction with other drugs is a significant consideration with Caverta. Concomitant use with nitrates is strictly prohibited due to severe hypotension risk. Caution is advised when used with alpha-blockers, as this may lead to symptomatic hypotension.
CYP3A4 inhibitors, such as ketoconazole, can elevate plasma concentrations of Sildenafil, necessitating dosage adjustments. Concomitant administration with potent CYP3A4 inducers might reduce efficacy. Interactions with erythromycin or protease inhibitors should be monitored closely. Grapefruit juice may also impact metabolism.
Toxicity Levels of Sildenafil Citrate
Toxicological evaluations of Sildenafil reveal a high safety margin when used as directed. Overdosage may manifest as prolonged erection, severe dizziness, or loss of consciousness. Laboratory studies emphasize caution, especially in patients with renal or hepatic impairment, as metabolism and clearance are altered.
Acute toxicity studies demonstrate that doses several times higher than the maximum recommended human dose lead to significant adverse effects. Chronic exposure data suggest that long-term use does not lead to carcinogenicity. Therapeutic monitoring and adherence to prescribed doses mitigate toxicity risks.
Availability of Caverta Over The Counter
Caverta is not available over the counter; it requires a prescription. This regulation ensures appropriate usage and minimizes misuse. The necessity of a prescription underscores the importance of medical oversight. Access through legitimate channels prevents counterfeit risk.
Healthcare professionals assess the suitability of Caverta on a case-by-case basis. They consider factors like age, health status, and potential drug interactions. While this may limit immediate access, it guarantees safety and efficacy for patients. Such control also deters unsupervised usage.
| Feature | Details |
|---|---|
| Metabolism | Hepatic, via CYP3A4 |
| Excretion | Renal and fecal |
- Indications: Treatment of erectile dysfunction
- Contraindications: Concurrent nitrate therapy
- Storage: Store in a cool, dry place
Data source:
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